In a medium mixing bowl, combine 10 ounces of drained canned tuna, 1/4 cup of mayonnaise, 1 large egg, 1/2 cup of panko breadcrumbs, 1 tablespoon of lemon juice, 1 teaspoon of garlic powder, and 1 teaspoon of onion powder. Season with salt and pepper to taste. Mix until just combined.

Using your hands, form the mixture into 6-8 patties, each about 3/4-inch thick. Cover the patties and chill them in the refrigerator for 10 minutes.

In a large skillet, pour in 2 tablespoons of neutral oil and heat it over medium-high heat until shimmering.

Carefully place the chilled patties into the hot skillet and cook without moving them for about 3-4 minutes until golden brown.

Using a spatula, gently flip the patties and cook for another 3-4 minutes until golden brown and cooked through.

Transfer the patties to a plate lined with paper towels to drain any excess oil. Serve with fresh lemon wedges or your favorite dipping sauce.