Prepare a large pot of boiling water and blanch the broccoli florets for about 2 minutes until bright green, then transfer to an ice bath.

In a mixing bowl, combine the blanched broccoli, cream cheese, cheddar, parmesan, egg, garlic powder, onion powder, salt, and pepper, mixing until fully incorporated.

Shape the mixture into balls or small patties about 1-2 inches in diameter for even cooking.

Roll each popper in panko breadcrumbs on a clean surface until evenly coated.

Preheat the air fryer to 375°F (190°C) for 5 minutes.

Place the coated poppers in the air fryer basket in a single layer, lightly spray with cooking spray, and cook for 10-12 minutes, flipping halfway through.

Let the poppers cool for a couple of minutes before serving them with your favorite dipping sauces.