As the oven hums with anticipation, the mouthwatering scent of garlic and butter begins to fill my kitchen. I can already picture friends gathering around the table, their eyes lighting up at the sight of my Garlic Butter Shrimp Scampi Lasagna. This delightful dish combines the best of both worlds—seafood and comfort food—in a way that’s not just indulgent but also surprisingly easy to whip up. With creamy layers of tender shrimp, luscious cheese, and the perfect hint of lemon, it’s a guaranteed crowd-pleaser, whether it’s a cozy weeknight dinner or a festive gathering. Plus, if you’re looking for a gluten-free option, I’ve got you covered! Are you ready to elevate your lasagna game? Let’s dive in!

Why is this lasagna a must-try?
Irresistible Flavor: Captivating layers of creamy garlic butter sauce and succulent shrimp create a flavor explosion that will leave you craving more.
Quick Preparation: Effortlessly whip up this dish in under an hour, making it perfect for busy weeknights or impromptu gatherings.
Family Favorite: Bring everyone to the table with this crowd-pleaser. It’s an ideal recipe to impress guests while keeping everyone satisfied, much like my popular Garlic Butter Steak or Cheesy Garlic Bread.
Versatile Ingredients: Feel free to swap in your favorite seafood or add seasonal veggies like spinach for a nutritious twist!
Comforting Texture: Savor the divine blend of gooey cheese, tender shrimp, and al dente pasta, making every bite a warm embrace of comfort.
Garlic Butter Shrimp Scampi Lasagna Ingredients
For the Sauce
- Butter – Adds rich flavor and assists in cooking shrimp; for a lighter option, substitute with olive oil.
- Garlic – Provides aromatic depth to the sauce; fresh is recommended for maximal impact.
- Crushed Red Pepper Flakes – Adds an optional spice kick; omit for a milder dish.
- Heavy Cream – Creates a creamy, luscious sauce; can substitute with half-and-half for a lighter version but may alter flavor.
- Chicken Broth – Enhances flavor depth; vegetable broth works well for a lighter option.
- Lemon Zest and Juice – Brightens the dish and balances richness; fresh is ideal for the best flavor.
- Salt and Black Pepper – Essential for balanced flavors.
For the Shrimp
- Large Shrimp – The star protein that offers sweetness and tenderness; can substitute with scallops or lobster, adjusting cooking times accordingly.
For the Lasagna
- Lasagna Noodles – Forms the structure of the dish; gluten-free noodles can be used to accommodate dietary needs.
- Ricotta Cheese – Adds creaminess and a rich texture; cottage cheese can be a lighter substitute.
- Mozzarella Cheese – Melts beautifully for a gooey texture; low-fat mozzarella works for a lighter dish.
- Parmesan Cheese – Adds nuttiness and enhances flavor; freshly grated offers the best taste.
- Fresh Parsley – Garnish for freshness and color; can be substituted with basil for a different herbal note.
- Olive Oil – Used to drizzle the baking dish, contributing flavor while preventing sticking.
This Garlic Butter Shrimp Scampi Lasagna is sure to become a staple in your recipe collection, bringing warmth and delight to your table!
Step‑by‑Step Instructions for Garlic Butter Shrimp Scampi Lasagna
Step 1: Prepare Shrimp
In a large skillet, melt 3 tablespoons of butter over medium heat. Add 4 cloves of minced garlic and sauté until fragrant, about 1 minute. Toss in 1 pound of large shrimp and a pinch of crushed red pepper flakes. Cook the shrimp for 2-3 minutes, or until they turn pink and opaque. Remove the shrimp from the skillet and set aside on a plate while you prepare the sauce.
Step 2: Make Sauce
In the same skillet, pour in 1 cup of heavy cream and 1 cup of chicken broth, stirring to combine. Add the zest and juice of 1 lemon, along with salt and black pepper to taste. Bring the mixture to a simmer over medium heat, allowing it to thicken slightly for about 5 minutes while stirring occasionally. This creamy garlic sauce will perfectly complement your Garlic Butter Shrimp Scampi Lasagna.
Step 3: Combine Cheeses
Lower the heat and stir in 1 cup of ricotta cheese until well incorporated. Gradually add 1 cup of shredded mozzarella and ½ cup of grated Parmesan cheese, mixing until the cheese is melted and the sauce is smooth. Once combined, gently fold the sautéed shrimp back into the skillet, ensuring they are well coated with the creamy mixture.
Step 4: Assemble Lasagna
Preheat your oven to 375°F (190°C). Start assembling the garlic butter shrimp scampi lasagna by spreading a thin layer of the shrimp and sauce mixture at the bottom of a 9×13 inch baking dish. Layer with lasagna noodles, then alternate layers of the shrimp sauce, more noodles, and the cheese mixture. Repeat until you run out of ingredients, finishing with a generous layer of mozzarella on top.
Step 5: Bake
Cover the lasagna with aluminum foil and place it in the preheated oven. Bake for 25 minutes to cook the noodles through. Afterward, remove the foil and continue baking for an additional 10 minutes, or until the cheese is golden and bubbling. The aroma of the Garlic Butter Shrimp Scampi Lasagna will fill your kitchen, tempting everyone nearby.
Step 6: Garnish and Serve
Once out of the oven, let your lasagna rest for 5-10 minutes before slicing. This resting period makes it easier to serve neat portions. Garnish with freshly chopped parsley for a pop of color and flavor. Now, slice into your delicious Garlic Butter Shrimp Scampi Lasagna and enjoy the comforting layers with family and friends!

Expert Tips for Garlic Butter Shrimp Scampi Lasagna
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Perfectly Cooked Shrimp: Ensure you sauté the shrimp just until they turn pink and opaque; overcooked shrimp can become rubbery and tough.
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Let It Rest: Allow the lasagna to rest for 5-10 minutes after baking. This ensures cleaner slices and lets the flavors meld together beautifully.
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Layer Smart: Use a mix of both sauce and cheese between the layers to prevent the noodles from drying out, keeping your garlic butter shrimp scampi lasagna moist and delicious.
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Cheese Choice: Freshly grated cheeses, especially Parmesan, will enhance the flavor significantly compared to pre-shredded options, making your dish even more indulgent.
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Gluten-Free Options: If you’re making a gluten-free version, always ensure the lasagna noodles are certified gluten-free to avoid cross-contamination and maintain delicious texture.
What to Serve with Garlic Butter Shrimp Scampi Lasagna
Imagine the delightful aroma wafting through your kitchen as you enjoy a meal that tantalizes both the senses and the soul.
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Garlic Bread: Warm, toasted slices of garlic bread provide a crunchy texture that complements the creamy lasagna beautifully. It’s perfect for dipping and savoring every bit of that luscious sauce.
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Caesar Salad: Crisp romaine, garlicky croutons, and a creamy dressing bring a fresh crunch to the table, balancing the richness of the lasagna with a zesty contrast. You can never go wrong with this classic!
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Grilled Asparagus: The earthy flavors of lightly seasoned grilled asparagus add a tender, slightly smoky bite, enhancing the overall dining experience. It’s a perfect way to incorporate greens into your meal.
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Lemonade or Sparkling Water: A refreshing glass of homemade lemonade or sparkling water with lemon slices can cleanse your palate and bring out the dish’s bright flavors. A hint of sweetness or fizz makes every bite more delightful.
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Roasted Vegetables: Seasoned roasted vegetables like bell peppers, zucchini, and cherry tomatoes offer a vibrant addition, adding color and a nutritious boost to your meal. Their natural sweetness pairs perfectly with the seafood flavors.
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Tiramisu: For dessert, indulge in a slice of creamy tiramisu. The rich coffee and cocoa flavors provide a satisfying finish to your hearty dinner, complementing the aromatic layers of the lasagna.
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Chardonnay or Sauvignon Blanc: A chilled glass of Chardonnay or a crisp Sauvignon Blanc will elevate your meal. The citrus undertones and acidity are a joyous match for the shrimp and creamy sauce.
With these pairings, your Garlic Butter Shrimp Scampi Lasagna will shine even brighter and make your gathering memorable!
Storage Tips for Garlic Butter Shrimp Scampi Lasagna
Fridge: Store leftover lasagna in an airtight container for up to 3 days. Ensure it’s fully cooled before sealing to maintain freshness.
Freezer: For longer storage, wrap portions tightly in plastic wrap and aluminum foil, then freeze for up to 2 months. Label for easy identification.
Reheating: To reheat, thaw in the fridge overnight and bake at 350°F (175°C) until warmed through, about 20-25 minutes. Enjoy the flavors of your garlic butter shrimp scampi lasagna once again!
Make-Ahead: Assemble the lasagna a day in advance and refrigerate, adding an extra 10-15 minutes to the baking time when cooking from chilled.
Garlic Butter Shrimp Scampi Lasagna Variations
Feel free to explore these tempting twists that will let your creativity shine in the kitchen!
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Vegetable Boost: Add sautéed spinach or kale between layers for a nutritious pop of color and flavor.
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Cheese Exploration: Substitute ricotta with creamy goat cheese for a tangy contrast or blend in some provolone for a unique twist. Just imagine that delightful creaminess!
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Herb Infusion: Swap parsley for fresh basil or dill to brighten the dish, providing a different aromatic experience that family and friends will love.
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Seafood Swap: Try using scallops or even lobster meat in place of shrimp for a luxurious take on this classic dish. Just keep an eye on those cooking times!
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Dairy-Free Option: Use a dairy-free cream substitute like coconut cream and nut-based cheese for a vegan twist that still feels indulgent.
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Heat Factor: Kick up the spice with additional crushed red pepper flakes or a dash of hot sauce mixed into the sauce for a fiery flavor lift.
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Nutty Flavor: Sprinkle toasted pine nuts on top before serving for a delightful crunch and an unexpected nutty flavor.
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Pasta Alternatives: Experiment with zucchini noodles or eggplant slices for a low-carb, gluten-free alternative that’s just as satisfying as the traditional version.
With variations like these, your Garlic Butter Shrimp Scampi Lasagna will always capture the hearts—and taste buds—of everyone at the table! For more delicious ideas, don’t miss out on my Garlic Chicken Gnocchi Skillet or a simple yet delectable Grilled Shrimp Bowl with Corn Salsa.
Make Ahead Options
These Garlic Butter Shrimp Scampi Lasagna is perfect for busy weeknights and can save you precious time! You can assemble the entire lasagna up to 24 hours in advance. Simply prepare it as instructed, cover it tightly with plastic wrap or aluminum foil, and refrigerate. For optimal quality, make sure to allow it to come to room temperature for about 30 minutes before baking, and increase the baking time by 10-15 minutes to ensure it’s heated through. This way, you’ll have a delicious, comforting meal ready to pop in the oven whenever you’re pressed for time! Just follow these prep tips to keep it just as tasty as when freshly made.

Garlic Butter Shrimp Scampi Lasagna Recipe FAQs
What kind of shrimp should I use for the lasagna?
I recommend using large shrimp for this Garlic Butter Shrimp Scampi Lasagna, as they offer a tender texture and sweet flavor. If you’re feeling adventurous, scallops or even lobster can be substituted, just remember to adjust cooking times accordingly to ensure everything remains perfectly tender.
How should I store leftover lasagna?
Store leftover Garlic Butter Shrimp Scampi Lasagna in an airtight container in the refrigerator for up to 3 days. Make sure it has cooled completely before sealing, as this helps maintain its flavorful freshness!
Can I freeze the lasagna, and if so, how?
Absolutely! To freeze, wrap portions tightly in plastic wrap, followed by aluminum foil for added protection against freezer burn. You can freeze it for up to 3 months. When you’re ready to enjoy it again, simply thaw it in the fridge overnight, then reheat in the oven at 350°F (175°C) for about 20-25 minutes or until warmed through. Trust me—this makes for a wonderful “cook once, enjoy twice” meal!
What if my garlic butter sauce is too thick?
If you find that your sauce has thickened too much while simmering, add a splash of chicken broth or heavy cream to thin it out. Stir well, and it should return to that creamy consistency you’re aiming for. Don’t hesitate to adjust to your preferred creaminess level!
Can I make this lasagna ahead of time?
Yes, you can! If you want to prepare this dish in advance, feel free to assemble the entire lasagna up to a day before and refrigerate it. Just remember to add an extra 10-15 minutes to your baking time when cooking from chilled, ensuring everything gets heated just right. It’s such a lifesaver for busy weeknights!
Is this dish gluten-free?
The lovely thing about this Garlic Butter Shrimp Scampi Lasagna is that you can easily make it gluten-free by using certified gluten-free lasagna noodles. Always double-check the packaging to ensure they meet your dietary needs, and you’ll be good to go!

Garlic Butter Shrimp Scampi Lasagna for a Cozy Night In
Ingredients
Equipment
Method
- In a large skillet, melt 3 tablespoons of butter over medium heat. Add 4 cloves of minced garlic and sauté until fragrant, about 1 minute.
- Toss in 1 pound of large shrimp and a pinch of crushed red pepper flakes. Cook the shrimp for 2-3 minutes, or until they turn pink and opaque. Remove the shrimp from the skillet and set aside on a plate.
- In the same skillet, pour in 1 cup of heavy cream and 1 cup of chicken broth, stirring to combine. Add the zest and juice of 1 lemon, along with salt and black pepper to taste. Bring to a simmer over medium heat, allowing it to thicken slightly for about 5 minutes while stirring occasionally.
- Lower the heat and stir in 1 cup of ricotta cheese until well incorporated. Gradually add 1 cup of shredded mozzarella and ½ cup of grated Parmesan cheese, mixing until the cheese is melted and the sauce is smooth. Gently fold the sautéed shrimp back into the skillet.
- Preheat your oven to 375°F (190°C). Start assembling the lasagna by spreading a layer of the shrimp and sauce mixture at the bottom of a 9x13 inch baking dish. Layer with lasagna noodles, then alternate layers of the shrimp sauce and cheese mixture. Finish with a layer of mozzarella on top.
- Cover the lasagna with aluminum foil and place it in the oven. Bake for 25 minutes. Remove the foil and continue baking for an additional 10 minutes until the cheese is golden and bubbling.
- Let the lasagna rest for 5-10 minutes before slicing. Garnish with freshly chopped parsley and serve.

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